Pictured left to right: P. McKiernan, J. Squires
James E. Squires, Patrick McKiernan. Molecular Mechanisms in Pediatric Cholestasis. Gastroenterology Clinics of North America, 2018-12-01, Volume 47, Issue 4, Pages 921-937. PMID: 30337041.
ABSTRACT
Pediatric cholestasis often results from mechanical obstruction of the biliary tract or dysfunction in the processes of forming and excreting bile. Various genetic defects with resulting molecular inaccuracies are increasingly being recognized, often with specific clinical characteristics. Identifying of the molecular abnormality can enable implementation of timely, appropriate treatment in some affected individuals and provide prognostic indicators for both families and care teams.
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