Eric Lagasse, PharmD, PhD

PLRC researcher Dr. Eric Lagasse, PhD, PharmD, and his company LyGenesis have launched a Phase II clinical trial in which healthy donor hepatocytes are transplanted into lymph nodes of patients with liver failure. The news Article was published in Science: ‘Mini liver’ will grow in person’s own lymph node in bold new trial. The first patient was treated March 25th and is doing well so far. The procedure has worked in mice, dogs and pigs thus far, and is being used primarily as a stop-gap measure to bridge patients until a transplantable liver becomes available. 

Researchers injected a mouse’s lymph node with liver cells (green), converting the organ into a ‘mini liver’. Credit: Lagasse Lab