Co-Directors: Jianhua Luo, MD, PhD and Silvia (Shuchang) Liu, PhD
Assistant Director: Yanping Yu, MD, PhD
Based on your needs, please fill out the service request form and return it to Dr. Luo and Dr. Liu for services and further consultation. GSBC-Service Request-Form
Expertise of Dr. Jianhua Luo’s group:
Expertise of Dr. Silvia Liu’s group:
High throughput genomic data analysis by machine learning and statistical methods:
Clustering, classification, bi-clustering, meta-analysis, omics data analysis, linear models, regression, probability theory, gene regulation, data preprocessing, feature selection, dimension reduction, biomarker detection, pathway analysis, differential expression analysis, microarray (mRNA, SNP, etc) data analysis, clinical/survival data analysis
Next Generation Sequencing (NGS) and Long-read Sequencing data analysis:
Transcriptome sequencing (RNA-Seq), whole genome sequencing (WGS), whole exome sequencing (WES), Chip-Seq, Oxford Nanopore sequencing, quality control (QC), trimming, alignment, fusion gene detection, gene expression, structural variation (SV) detection, copy number variation (CNV) analysis, SNP calling, peak calling, long-read sequencing (third-generation) analysis
- For Liu PLRC Faculty Profile Page, please click here.
For Systems Biology services, please click here.
Available Services
- U133 2.0 array
- R230 2.0 array
- R430 2.0 array
- CLARIOM array
- SNP 6.0 array
- CytoscanHD
- OncoScan array
- Human exon 1.0 ST array
- Expression arrays for porcine, bovine, drosophila, etc.
- Library ready sequencing
- Library prep from raw sample or RNA
- Library prep for whole genome from raw sample or DNA
- Library prep for exome from raw sample or DNA
- Library prep for methylation from raw sample or DNA
- Library prep for single cell sequencing with individual molecule barcoded
- Whole genome sequencing for de novo assembly, structural variation, single nucleotide variation and resequencing analyses
- Transcriptome sequencing for RNA isofrom and fusion transcript analyses using direct RNA sequencing and ligation sequencing
- Targeted sequencing include amplicons, sequence capture and exome
- Epigenetic sequencing including methylation, histone modification and non-coding RNA activity
- Microbiome sequencing
- Our center is equipped with ControllerTM from 10x Genomics, Inc. We provide collaboration on the analysis of 3’ barcoded and 5’ barcoded single-cell transcriptome sequencing to classify cell type on individual cell level. We also provide exome, copy number and ATAC sequencing for the chromosome structure analysis, all on the single-cell level. Single-cell classification provides high-resolution analysis on cell population. It is a new tool that enables us to understand organ development, cancer evolution and immune cell activation in individual cell level.
- Our center is equipped with a state-of-the-art AVITI/Illumina system which can provide whole genome, exome, methylation sequencing as well as single-cell sequencing and Visium Spatial cytassist sequencing for FFPE with barcodes at reduced costs.
Basic analysis services include:
- RNA-seq and microarray gene expression
- Single cell RNA-seq
- microRNA expression
- Pathway enrichment analysis
- Methylation
- Microbiome
- Multi-scale causal modeling (omics and clinical data)
- Predictive modeling / machine learning
- Biomarker identification