Dr Kari Nejak Bowen, PhD , PLRC Enrichment Director and Dr. Paul Monga, MD, PLRC Director, coauthored a review article in Hepatology entitled ”Wnt-β-catenin in hepatobiliary homeostasis, injury, and repair. “
ABSTRACT:
Wnt-β-catenin signaling has emerged as an important regulatory pathway in liver, playing key roles in zonation and mediating contextual hepatobiliary repair after injuries. In this review, we will address the major advances in understanding the role of Wnt signaling in hepatic zonation, regeneration, and cholestasis-induced injury. We will also touch upon some important unanswered questions, and discuss the relevance of modulating the pathway to provide therapies for complex liver pathologies that remain a continued unmet clinical need.
