Research Interests: I employ computational and systems biology approaches to inflammation in multiple disease states (sepsis/trauma, liver diseases, wound healing, chronic inflammatory diseases, and cancer), coupled to biochemical, cellular, animal, and clinical studies, with the goal of rational inflammation reprogramming. My research is supported by the NIH and Department of Defense.
Ongoing Research Studies:
1. Collaboration with Dr. Jorg Gerlach on a hepatocyte-based biohybrid device for adaptive control of inflammation.
2. Collaboration with Drs. Robert Squires and Ruben Zamora on systems biology approaches to help decipher the inflammatory complexity of Pediatric Acute Liver Failure.
3. Collaboration with Dr. Paulo Fontes aimed at defining novel inflammatory pathways associated with a novel extracorporeal perfusion system for liver transplantation.
4. Collaboration with Drs. Ira Fox and Alejandro Soto-Gutierrez on systems biology approaches to liver failure.
Research Service: Our laboratory, while not a designated core facility, has extensive experience in inflammation biomarker analyses (e.g. Luminex™, ELISA, etc.) in multiple clinical settings, combined with cutting edge computational modeling.
Director, Center for Inflammation and Regenerative Modeling
Professor of Surgery, Immunology, Computational and Systems Biology, Clinical and Translational Science, Bioengineering, and Communication Science and Disorders
Health Science School