Dr. Kleyman’s research efforts are primarily directed at the study of epithelial Na channels (ENaCs) and large conductance Ca2+ activated K (BK) channels. Recent work has focused on elucidating mechanisms by which extracellular proteases, small ions and mechanical forces modulate ENaC gating. He is studying how ENaC modification by glycans and palmitate affect channel trafficking and activity. His group as identified novel functional human ENaC variants and are assessing how these variants affect blood pressure in rodent models and humans. Studies are also directed at examining the regulation of BK channels in renal collecting tubules by WNK kinases and by dietary potassium. Dr. Kleyman serves as the director of our Pittsburgh Center for Kidney Research, and directs T32 and T35 training grants.