Robert O'Doherty, PhD

Robert O’Doherty, PhD*

E1140 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15261

Liver-Related Work

Research Interests: My overarching research interests are in questions related to states of over nutrition and resulting metabolic disturbances, most notably obesity, NAFLD, and Type 2 Diabetes. I have accumulated nearly twenty-five years experience in this arena, utilizing a range of metabolic, physiological, biochemical, molecular and immunological approaches in a range of in vivo (rodent), ex vivo (primary tissue and cells), and in vitro (immortal cell lines) models.  A major focus of our current research is in understanding mechanisms by which nutrient oversupply leads to immune system activation and consequent metabolic dysregulation, using the liver and adipose tissue as model target tissues. I am Co-Director of the Center for Metabolism and Mitochondrial Medicine (C3M), which provides intellectual and practical expertise and technical assistance to researchers with little experience in these areas. I am also Director of the T32 Training Program in Endocrinology, Diabetes and Metabolism.

Research Service: The Center for Metabolism and Mitochondrial Medicine (C3M) facilitates and supports research that addresses the role of metabolism and mitochondria in physiology and their contribution to disease pathology, with the goal of translating this knowledge into strategies for diagnosis and treatment of disease. We seek to provide an institutional focal point for PI’s whose research in the area of metabolic and/or mitochondrial diseases would benefit from collaborations and interactions with a like-minded group of investigators. We utilize center resources to provide project and grant support, to provide access to and training in platform technologies, and to sponsor educational and training programs.


Professor of Medicine
Professor of Biochemistry and Molecular Genetics
Director, T32 Diabetes and Endocrinology Training Program
Director, Center for Metabolic and Mitochondrial Medicine (C3M)
Department of Medicine – Division of Endocrinology and Metabolism