Dr. Bao’s lab has ongoing collaborations with Dr. Paul Monga and Dr. Aatur Singhi on the investigation of tumor-immune interactions in liver, and its role in therapy response and resistance.

Dr. Bao has extensive experience extracting features from multi-dimensional space with annotated clinical outcomes to discover novel gene signatures and therapeutic targets. Her research laboratory develops new analytical and statistical methods to integrate multi-omics, metabolic, microbial, and spatially resolved transcriptomics/proteomics data with major contributions to the understanding of immune exclusion in the tumor microenvironment and modulation of responsiveness to immunotherapy, including the discovery of tumor-intrinsic oncogenic pathways and microbial communities associated with anti-PD1 efficacy. These findings are of particular importance because they provide the scientific rationale for new trials that combine therapeutic targets, such as IDH1 inhibitors, with anti-PD1. I am the Co-Leader of Bioinformatics/Biostatistics Core on multiple SPORE grants, including the Melanoma and Skin Cancer SPORE, and Head and Neck Cancer SPORE.

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View Dr. Bao’s NIH Report on nih.gov

View Dr. Bao’s publications on PubMed

Associate Professor of Medicine, University of Pittsburgh

Co-Director of Cancer Bioinformatics, UPMC Hillman Cancer Center