Research in the Weisz lab focuses broadly on understanding how membrane traffic in proximal tubule cells responds to physiologic cues to maintain kidney function. Her team is unraveling the mechanisms by which newly synthesized proteins are sorted and delivered to the appropriate plasma membrane domains of differentiated kidney cells. Additionally, she has been generating new in vitro and ex vivo systems, including disease models, with which to unravel how proximal tubule cells in the kidney alter their endocytic and ion transport capacity in response to changes in tubular flow and the accompanying fluid shear stress. Her studies have direct implications for the understanding and treatment of genetic and other disorders that result in tubular proteinuria and eventually lead to kidney failure, including Lowe syndrome and sickle cell disease.