khoo

Nicholas (Nick) Khoo, PhD

E1342 BST
200 Lothrop St
Pittsburgh, PA 15261


Liver-Related Work

My research has largely focused on the mechanisms by which bioactive lipids, particularly those derived from the oxidative inflammatory reactions of nitric oxide called nitro-fatty acids, prevent the pathogenesis of obesity-related metabolic diseases. Currently, we are exploring the mechanistic role of hyperuricemia in fructose-driven NAFLD and the progression to NASH by targeting enzymes responsible for uric acid production pharmacologically as well as using novel gain- and loss-of-function approaches with genetic mice.

Selected Publications:

View Dr. Khoo’s publications on PubMed

Collaborations:

w/ Drs. Arteel, Jurczak and Schopfer