Chair, Department of Medicine, UPMC
Director, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (VMI), University of Pittsburgh

Dr. Gladwin specializes in diagnosing and treating people pulmonary hypertension and sickle cell disease. He’s an expert in heart and lung complications of sickle cell disease, which occur more frequently as patients are aging.

Since 1998, Dr. Gladwin’s research has led to numerous scientific discoveries such as:

• The nitrite anion is a circulating storage pool for NO bioactivity that regulates hypoxic vasodilation and the cellular resilience to low oxygen and ischemia.
• A novel physiological function for hemoglobin as an electronically and allosterically-regulated nitrite reductase.
• The characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction.
• The mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertens