James Squires, MD, M

James Squires, MD, MS*

One Children's Drive
4401 Penn Avenue
FP 6th Floor
Pittsburgh, PA 15224

Liver-Related Work

Clinical and Research Interests: I am a Clinical Hepatologist working in the field of pediatrics with special interests in pediatric liver diseases and pediatric liver transplant. I care for children and families with pediatric liver disease including biliary atresia, inherited liver diseases, autoimmune hepatitis, non-alcoholic steatohepatitis, and primary sclerosing cholangitis. I am a member of the Childhood Liver Disease Research Network (ChiLDReN), an NIH funded consortium working together to improve the lives of children and families dealing with rare cholestatic liver diseases. I am also a member of the Studies in Pediatric LIver Transplant (SPLIT), a multifaceted organization focused on improving outcomes for children receiving liver transplantation.  
Ongoing Research Studies:
  1. Collaboration with ChiLDReN to determine the prevalence, and factors associated with, neurocognitive deficiencies in older children with biliary atresia alive with their native liver. 
  2. Determining the clinical variability following partial external biliary diversion in familial intrahepatic cholestasis 1 (FIC) deficiency.
  3.  Collaboration with Graft Injury Group Observing Long-term Outcomes (GIGOLO) to determine the incidence and associated factors of idiopathic graft fibrosis in asymptomatic pediatric liver allograft recipients.
  4. Determining the diagnostic and predictive capabilities of novel urine biomarkers of acute kidney injury in the peri-operative period in pediatric liver transplant.
  5. Ancillary study of the Pediatric Acute Liver Failure (PALF) study group to explore the clinical decision making process as it relates to liver transplantation in children with acute liver failure.
  6. Ancillary study to the Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT) consortium exploring the prevalence and phenotypic characteristics of ulcerative colitis-associated liver disease.
Research Service: The Liver Clinic at the Children’s Hospital of Pittsburgh is designed to offer timely, multi-disciplinary, sub-specialized care to children with a broad array of hepatobiliary diseases. The wide-ranging composition of the clinic patients encompasses local, regional, and international referrals for the evaluation of liver disease, second-opinion and transplant evaluations, and management of non-operable patients with chronic liver disease. This resource enables recruitment of patients for clinical studies and for the collection of samples used to further understand and explore hepatobiliary diseases affecting children. For details please contact me at the address above.


Faculty – Clinician, Physician
Department of Pediatrics – Division of Gastroenterology, Hepatology, and Nutrition