Eric Goetzman, PhD

Eric Goetzman, PhD*

Rangos 5117
4401 Penn Avenue
Pittsburgh, PA 15224


Liver-Related Work

Research Interests: My area of expertise is in liver energy metabolism and the fatty acid oxidation pathway in particular. My laboratory utilizes substrate flux assays (radiolabeled substrates), Oroboros high-resolution respirometry, and various biochemical assays to study hepatic mitochondrial function in mouse models.
Ongoing Research Studies:
  1. Role of sirtuin deacylases in regulating the mitochondrial fatty acid oxidation (FAO) pathway (NIH-funded). We are using a combination of in vitro and in vivo approaches to identify key lysine post-translational modifications on mitochondrial enzymes. A particular focus is on how lysine modifications may alter the assembly of large metabolic protein super-complexes in the mitochondria.
  2. Co-investigator with Dr. Ed Prochownik on an NIH-funded project investigating the role of C-Myc in regulating metabolism during liver tumorigenesis.
  3. Role of sirtuins in maintaining the function of peroxisomes during aging and tumorigenesis in the liver. This is a pilot project—in collaboration with Donna Stolz of the Center for Biologic Imaging—that was recently funded by the UPMC aging research group “Stimulating Pittsburgh Research in Geroscience (SPRIG).”

 

Assistant Professor
Department of Pediatrics