Liver-Related Work

The Clark Lab research program focuses on liver metastasis. Our investigations focus on determining the operative molecular underpinnings of metastatic dormancy and recurrence within the liver in order to apply such findings to identify new therapeutic targets to prevent recurrence and turn metastatic disease into a chronic, manageable disease. We utilize a novel all-human ex vivo 3D hepatic microphysiological system (MPS) to study this evolving metastatic phenomenon. This MPS has not only enabled the recreation of dormant-emergent metastatic cancer progression as observed in vivo but also the identification of mechanisms, biomarkers, and new therapeutic opportunities to target the various stages of metastasis.

Selected Publications:

View Dr. Clark’s publications on PubMed

Collaborations:

1. Collaborated and published with Drs. Alan Wells, Donna Stolz, Raman Venkataramanan, Lans Taylor, Mo Ebrahimkhani, and Ira Fox.