Dr. Alina Ostrowska

Alina Ostrowska, PhD

Research Assistant Professor

Research Assistant Professor

S448 Biomedical Science Tower

200 Lothrop Street

Pittsburgh, PA 15261

Liver-Related Work

Clinical and Research Interests: Dr. Ostrowska’s clinical interest is focused on providing substantial scientific and technical input and expertise in all aspects of primary human hepatocyte isolation, culture and transplantation. She is currently working on the development of an independent research program to investigate mechanisms of primary hepatocyte cryobiology and cold preservation. She is also interested in the characterization of human hepatocytes isolated from non-transplantable livers, including evaluation of CYP450s activities in cells isolated from explanted cirrhotic liver specimens obtained from patients undergoing OLT. Participation in clinical trial of hepatocyte transplantation.

There is a pressing need for alternative therapeutic methods effective in the treatment of patients with liver insufficiency. Isolated human hepatocytes may be a viable alternative or adjunct to orthotopic liver transplantation in such patients. Dr. Ostrowska is defining and managing both preclinical and clinical trial strategy, ensuring all activities adhere to cGMP policies, as well as FDA regulations, and IND guidelines.

Selected Publications: View Dr. Ostrowska’s publications on pubmed

  1. Department of Surgery:
    1. Ira Fox, MD
    2. Kyle Soltys, MD
    3. Rakesh Sindhi, MD
    4. George Mazariegos, MD
  2. Center for Rare Disease Therapy
    1. Gerard Vockley, MD, PhD

Dr. Ostrowoska provides high quality, well characterized major types of human hepatic cells isolated from any type of diseased liver (pediatric or adult). In particular, providing the next generation of a variety of human hepatic tissue formats that incorporate state-of-the-art technologies and implementing new projects related to isolation and characterization of human hepatocytes and non-parenchymal liver cells.

Research Assistant Professor
Department of Pathology

Director of Human Liver Disease Lab