Dr. Juliane I. Beier, PhD., Assistant Professor in the Department of Medicine, in partnership with the US Environmental Protection Agency published a study on the effects of Vinyl Chloride exposure in the journal of Toxicological Sciences, entitled “Vinyl Chloride Enhances High Fat Diet-Induced Proteome Alterations in the Mouse Pancreas Related to Metabolic Dysfunction“.
Ge Y, Bruno M, Nash MS, Haykal Coates N, Chorley BN, Cave MC, Beier JI. Vinyl Chloride Enhances High Fat Diet-Induced Proteome Alterations in the Mouse Pancreas Related to Metabolic Dysfunction. Toxicol Sci. 2023 Mar 9:kfad024. doi: 10.1093/toxsci/kfad024. Epub ahead of print. PMID: 36892438.
Alterations in physiological processes in pancreas have been associated with various metabolic dysfunctions and can result from environmental exposures, such as chemicals and diet. It was reported that environmental vinyl chloride exposure, a common industrial organochlorine and environmental pollutant, significantly exacerbated metabolic-related phenotypes in mice fed concurrently fed high-fat diet but not low-fat diet. However, little is known about the role of the pancreas in this interplay, especially at a proteomic level. The present study was undertaken to examine the protein responses to VC exposure in pancreas tissues of C57BL/6J mice fed LFD or HFD, with focus on the investigation of protein expression and/or phosphorylation levels of key protein biomarkers of carbohydrate, lipid, and energy metabolism, oxidative stress and detoxification, insulin secretion and regulation, cell growth, development, and communication, immunological responses and inflammation, and biomarkers of pancreatic diseases and cancers. We found that the protein alterations may indicate diet-mediated susceptibility in mouse pancreas induced by HFD to concurrent exposure of low levels of inhaled VC. These proteome biomarkers may lead to a better understanding of pancreas-mediated adaptive or adverse response and susceptibility to metabolic disease.