Dr. David Geller, Richard L. Simmons Professor of Surgery and Co-Director of CBRPC, published a review article in American Journal of Physiology, Gastrointestinal and Liver Physiology, entitled, “The therapeutic potential of exosomes derived from different cell sources in liver diseases.”

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Pan Y, Tan WF, Yang MQ, Li JY, Geller DA. The therapeutic potential of exosomes derived from different cell sources in liver diseases. Am J Physiol Gastrointest Liver Physiol. 2022 Apr 1;322(4):G397-G404. doi: 10.1152/ajpgi.00054.2021. Epub 2022 Feb 2. PMID: 35107032; PMCID: PMC8917924.

David Geller, MD

Abstract

Exosomes are small nanovesicles with a size of approximately 40–120 nm that are secreted from cells. They are involved in the regulation of cell homeostasis and mediate intercellular communication. In addition, they carry proteins, nucleic acids, and lipids that regulate the biological activity of receptor cells. Recent studies have shown that exosomes perform important functions in liver diseases. This review will focus on liver diseases (drug-induced liver injury, hepatic ischemia-reperfusion injury, liver fibrosis, acute liver failure, and hepatocellular carcinoma) and summarize the therapeutic potential of exosomes from different cell sources in liver disease.