Lin FP, Ferrando AA, Dennis RA, Dunn MA, Kim WR, Duarte-Rojo A. Exercise-Induced Hyperammonemia Does Not Precipitate Overt Hepatic Encephalopathy. Hepatology. 2020 Jan 30;10.1002/hep.31148. doi: 10.1002/hep.31148. PMID: 31997375.
Moderate-to-vigorous exercise increases blood ammonia concentrations, potentially contributing to the development of hepatic encephalopathy (HE). Patients with end-stage liver disease (ESLD) often suffer from frailty or physical deconditioning as a result of sarcopenia, fluid overload/ascites, obesity and concomitant diseases. Exercise is therefore recommended for ESLD patients to reverse or halt progression of frailty/sarcopenia, as these conditions contribute to increased mortality.
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