Argemi J and Bataller R. Hepatocyte-stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids. Nat Rev Gastroenterol Hepatol 2020. PMID 31686014.
A new study demonstrates a novel role for an endocannabinoid in promoting hepatocyte steatosis. The study describes a mode of bidirectional communication between the alcohol-injured hepatocyte and the glutamate-activated hepatic stellate cell. This intercellular communication represents a novel targetable pathogenic mechanism that could lead to new strategies to prevent fatty liver disease progression to cirrhosis.
Refers to Choi, W.-M. et al. Glutamate signaling in hepatic stellate cells drives alcoholic steatosis. Cell Metab. https://doi.org/10.1016/j.cmet.2019.08.001 (2019).
For full text of review, please click here.