Satdarshan P. Monga. No Zones Left Behind: Democratic Hepatocytes Contribute to Liver Homeostasis and Repair. Cell Stem Cell; Volume 26, Issue 1, 2 January 2020, Pages 2-3.
Despite minimal turnover, liver cells possess immense regenerative capacity. Some studies suggest existence of a hepatocyte subset with such unique capabilities. However, in the current issue of Cell Stem Cell, three independent studies (Chen et al., 2020, Matsumoto et al., 2020, and Sun et al., 2020) demonstrate an equitable homeostatic and reparative potential of all hepatocytes, irrespective of their lobular location or ploidy status.
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